Sugi Predict

Sugi Predict / Compounds / SCHEMBL20567950

SCHEMBL20567950

SCHEMBL20567950

c1cn2c(ccc3cncnc32)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MKNK2 Q9HBH9 5/20 0.44
▸ DYRK1A Q13627 4/20 0.35
▸ CDK8 P49336 2/20 0.35
▸ ROCK1 Q13464 2/20 0.35
▸ KDR P35968 2/20 0.35
▸ MAP2K1 Q02750 2/20 0.35
▸ DYRK1B Q9Y463 2/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ MAP4K4 O95819 1/20 0.35
▸ CSF1R P07333 1/20 0.35
▸ PRKACA P17612 1/20 0.35
▸ ACVR1 Q04771 1/20 0.35
▸ MAP4K2 Q12851 1/20 0.35
▸ AURKB Q96GD4 1/20 0.35
▸ LIMK1 P53667 2/20 0.35
▸ CLK4 Q9HAZ1 2/20 0.35
▸ FLT1 P17948 1/20 0.35
▸ CDK9 P50750 1/20 0.35
▸ MKNK1 Q9BUB5 1/20 0.35
▸ EGFR P00533 6/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1368544 0.74 PARP1 (0.42) DYRK1ACDK8ROCK1KDRMAP2K1
SCHEMBL31624542 0.74 PARP1 (0.42) DYRK1ACDK8ROCK1KDRMAP2K1
SCHEMBL30837303 0.74 MAPKAPK2 (0.37) DYRK1ACDK8ROCK1KDRMAP2K1
SCHEMBL17164754 0.71 MKNK2 (0.41) MKNK2CHEK1LIMK1CLK4MKNK1
SCHEMBL31253437 0.69 MKNK2 (0.39) MKNK2EGFR
SCHEMBL30837293 0.68 PTGS1 (0.39) MKNK2CDK8CLK4KDM4EALDH1A1
SCHEMBL30990399 0.68 MKNK2 (0.44) MKNK2MKNK1EGFR
SCHEMBL30837299 0.67 LCK (0.38) MKNK2CDK8EGFRADORA3
SCHEMBL29644499 0.67 PI4KA (0.39) MKNK2DYRK1ACDK8ROCK1KDR
SCHEMBL2319181 0.66 MKNK2 (0.45) MKNK2MKNK1EGFRALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11091485-B2 Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) 2021-08-17 — — US disclosed
US-11091485-B2 Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) 2021-08-17 — — US disclosed
US-11091485-B2 Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) 2021-08-17 — — US disclosed
US-20200270251-A1 IMIDAZO[1',2':1,6]PYRIDO[2,3-D]PYRIMIDINE COMPOUND AS PROTEIN KINASE INHIBITOR SHENGKE PHARMACEUTICALS (JIANGSU) LTD. (CN) 2020-08-27 — — US disclosed
WO-2018214846-A1 IMIDAZO[1',2':1,6]PYRIDO[2,3-D]PYRIMIDINE COMPOUND AS PROTEIN KINASE INHIBITOR 成都优赛丽医药科技有限公司 2018-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200270251-A1 IMIDAZO[1',2':1,6]PYRIDO[2,3-D]PYRIMIDINE COMPOUND AS PROTEIN KINASE INHIBITOR CDK2, CDK4, CDK1 MKNK2 164/4885DYRK1A 437/4885CDK8 11/4885
US-11091485-B2 Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor CDK2, CDK4, CDK6 MKNK2 165/4885DYRK1A 427/4885CDK8 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.