Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TLR2 | O60603 | 7/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 7/20 | 0.44 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496022 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL22718245 | 0.86 | TEAD1 (0.74) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL29648434 | 0.84 | TEAD1 (0.65) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL24496331 | 0.82 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL24496081 | 0.81 | TEAD1 (0.56) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL24496380 | 0.80 | TEAD1 (0.54) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL29648374 | 0.80 | TEAD1 (0.54) | TEAD1YAP1TLR2TLR1FLT1 | |
| SCHEMBL24496020 | 0.79 | TEAD1 (0.52) | TEAD1YAP1KDM4EASPHRIOX2 | |
| SCHEMBL24496080 | 0.78 | TEAD1 (0.53) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL24496265 | 0.78 | TEAD1 (0.58) | TEAD1YAP1TLR2TLR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159986-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |