Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.65 |
| ▸ | YAP1 | P46937 | 1/20 | 0.65 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718245 | 0.93 | TEAD1 (0.74) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL24496133 | 0.84 | TEAD1 (0.60) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL24496331 | 0.84 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL24496022 | 0.84 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL29648281 | 0.84 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL24496033 | 0.84 | TEAD1 (0.59) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL29648345 | 0.84 | TEAD1 (0.59) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL29648384 | 0.83 | TEAD1 (0.59) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL24496097 | 0.83 | TEAD1 (0.59) | TEAD1YAP1TLR2TLR1PTGS2 | |
| SCHEMBL22718064 | 0.83 | TEAD1 (0.65) | TEAD1YAP1TLR2TLR1TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |