Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496354 | 1.00 | TEAD1 (0.47) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL22718104 | 0.90 | TEAD1 (0.49) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL29438921 | 0.90 | TEAD1 (0.49) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL29438915 | 0.88 | TEAD1 (0.49) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL22718251 | 0.88 | TEAD1 (0.49) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL29438917 | 0.88 | TEAD1 (0.49) | TEAD1YAP1MDM2NPSR1MAPT | |
| SCHEMBL22718289 | 0.85 | TEAD1 (0.47) | TEAD1YAP1MDM2NPSR1BMP1 | |
| SCHEMBL29438894 | 0.85 | TEAD1 (0.47) | TEAD1YAP1MDM2NPSR1BMP1 | |
| SCHEMBL22718146 | 0.85 | TEAD1 (0.51) | TEAD1YAP1BMP1LMNASMN1; SMN2 | |
| SCHEMBL29438859 | 0.85 | TEAD1 (0.51) | TEAD1YAP1BMP1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |