Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 5/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 2/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496208 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718131 | 0.92 | TEAD1 (0.58) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718221 | 0.91 | TEAD1 (0.56) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438880 | 0.84 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718190 | 0.84 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718252 | 0.81 | TEAD1 (0.59) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29648363 | 0.81 | CCR6 (0.41) | TEAD1YAP1MAPTCCR6 | |
| SCHEMBL24496211 | 0.81 | CCR6 (0.41) | TEAD1YAP1MAPTCCR6 | |
| SCHEMBL20779719 | 0.81 | TEAD1 (0.74) | TEAD1YAP1TNNI3KMAPTTLR2 | |
| SCHEMBL22718177 | 0.80 | TEAD1 (0.55) | TEAD1YAP1TNNI3KMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |