Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | GOT1 | P17174 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8821164 | 1.00 | APP (0.60) | APPPDE5AMAPTALDH1A1GAA | |
| SCHEMBL7390985 | 0.95 | APP (0.55) | APPPDE5AMAPTALDH1A1GAA | |
| SCHEMBL1622223 | 0.81 | CYP1A2 (0.61) | APPPDE5AMAPTALDH1A1HTT | |
| SCHEMBL2257238 | 0.79 | NPY5R (0.66) | APPPDE5AMAPTALDH1A1KDM4E | |
| SCHEMBL30960995 | 0.79 | NPY5R (0.66) | APPPDE5AMAPTALDH1A1KDM4E | |
| SCHEMBL15845651 | 0.78 | APP (0.64) | APPMAPTALDH1A1GAAHPGD | |
| SCHEMBL404108 | 0.78 | ALDH1A1 (0.53) | MAPTALDH1A1GAAHTTKDM4E | |
| SCHEMBL7390981 | 0.78 | PDE5A (0.57) | APPPDE5AMAPTALDH1A1HTT | |
| SCHEMBL10839105 | 0.78 | APP (0.70) | APPPDE5AMAPTHTTMEN1 | |
| SCHEMBL30125140 | 0.78 | APP (0.70) | APPPDE5AMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114466850-B | [1,2,4] Triazolo [1,5-C ] quinazolin-5-amine | 拜耳股份有限公司 | 2024-09-10 | — | — | CN | disclosed |
| EP-4013508-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | Bayer Aktiengesellschaft (DE) | 2022-06-22 | — | — | EP | disclosed |