Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 9/20 | 1.00 |
| ▸ | LATS2 | Q9NRM7 | 7/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 11/20 | 0.52 |
| ▸ | PRKCH | P24723 | 10/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 10/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 9/20 | 0.52 |
| ▸ | PRKCA | P17252 | 8/20 | 0.52 |
| ▸ | PRKCB | P05771 | 5/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20547754 | 1.00 | LATS1 (1.00) | LATS1LATS2PRKCDPRKCHPRKCE | |
| SCHEMBL21875401 | 0.87 | LATS1 (0.76) | LATS1LATS2PRKCDPRKCHPRKCE | |
| SCHEMBL20547822 | 0.78 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL31375852 | 0.77 | LATS1 (0.62) | LATS1LATS2 | |
| SCHEMBL20574254 | 0.75 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL20547844 | 0.73 | LATS1 (1.00) | LATS1LATS2 | |
| SCHEMBL3326352 | 0.71 | PRKCD (0.62) | LATS1LATS2PRKCDPRKCHPRKCE | |
| SCHEMBL3327782 | 0.70 | PRKCD (0.61) | LATS1LATS2PRKCDPRKCHPRKCE | |
| SCHEMBL3327404 | 0.69 | PRKCD (0.54) | LATS1LATS2PRKCDPRKCHPRKCE | |
| SCHEMBL3327608 | 0.69 | PRKCH (1.00) | LATS1LATS2PRKCDPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573511-B | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-110573511-B | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| EP-4142879-A1 | METHODS AND COMPOSITIONS FOR OCULAR CELL THERAPY | Novartis AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| CN-115667504-A | Methods and compositions for ocular cell therapy | 诺华股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-114703144-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114621222-A | 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2022-06-14 | — | — | CN | disclosed |