SCHEMBL31375852

SCHEMBL31375852

Nc1nc(NC2(C(F)(F)F)CC2)c2ccncc2c1-c1ccncc1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LATS1 O95835 20/20 0.62
LATS2 Q9NRM7 15/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20547822 0.77 LATS1 (1.00) LATS1LATS2
SCHEMBL20547754 0.77 LATS1 (1.00) LATS1LATS2
SCHEMBL29649730 0.77 LATS1 (1.00) LATS1LATS2
SCHEMBL20547844 0.72 LATS1 (1.00) LATS1LATS2
SCHEMBL31375799 0.69 LATS1 (0.52) LATS1LATS2
SCHEMBL20547836 0.67 LATS1 (1.00) LATS1LATS2
SCHEMBL21875401 0.67 LATS1 (0.76) LATS1LATS2
SCHEMBL20574254 0.64 LATS1 (1.00) LATS1LATS2
SCHEMBL20547460 0.64 LATS1 (1.00) LATS1LATS2
SCHEMBL1102696 0.59 NOTUM (0.46) LATS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114621222-B 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors 诺华股份有限公司 2024-12-17 CN disclosed