Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 11/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21836077 | 1.00 | POLR1A (0.62) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836068 | 0.99 | POLR1A (0.61) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL29649787 | 0.99 | POLR1A (0.61) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21798990 | 0.91 | POLR1A (0.59) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836076 | 0.89 | ALDH1A1 (0.73) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836067 | 0.88 | POLR1A (0.63) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836090 | 0.88 | POLR1A (0.60) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21993198 | 0.88 | ALDH1A1 (0.72) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836071 | 0.88 | POLR1A (0.60) | POLR1AALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21836072 | 0.88 | ALDH1A1 (0.72) | POLR1AALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247143-B | Pyridoquinazoline derivatives useful as inhibitors of protein kinases | 昂科斯特拉公司 | 2022-07-05 | — | — | CN | claimed |
| CN-111247143-B | Pyridoquinazoline derivatives useful as inhibitors of protein kinases | 昂科斯特拉公司 | 2022-07-05 | — | — | CN | disclosed |