Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692903 | 1.00 | LMNA (0.54) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL28469591 | 0.86 | PRMT5 (0.47) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL21353039 | 0.86 | PRMT5 (0.47) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL29933794 | 0.81 | LMNA (0.47) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL1241813 | 0.81 | LMNA (0.73) | LMNATSHRMAPK1HIF1AMTNR1A | |
| SCHEMBL29813063 | 0.80 | LMNA (0.56) | LMNAADRB2ADRB1 | |
| SCHEMBL28737943 | 0.79 | CYP1A2 (0.52) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL28737942 | 0.79 | CYP1A2 (0.52) | LMNAPRMT5WDR77KAT6ATSHR | |
| SCHEMBL29934037 | 0.79 | LMNA (0.45) | LMNAKAT6ATSHRMAPK1HIF1A | |
| SCHEMBL28738065 | 0.79 | CYP1A2 (0.52) | LMNAPRMT5WDR77KAT6ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563103-B | Modulators of beta-3 adrenergic receptors for the treatment or prevention of disorders related thereto | 艾尼纳制药公司 | 2022-05-27 | — | — | CN | disclosed |