SCHEMBL29650447

SCHEMBL29650447

Cc1nc2cc(C(F)(F)F)c(N3CCN(C)CC3)c(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(C(=O)O)csc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29650599 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650546 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650493 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866507 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650582 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650545 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650554 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650532 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650497 0.90 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650565 0.90 EIF4EBP1 (0.88) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220378821-A1 METHODS OF TREATING BRAF-MUTATED CANCER CELLS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2022-12-01 — — US disclosed
EP-3993875-A1 METHODS OF TREATING BRAF-MUTATED CANCER CELLS EFFECTOR THERAPEUTICS, INC. (US) 2022-05-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220378821-A1 METHODS OF TREATING BRAF-MUTATED CANCER CELLS BRAF, EIF4EBP1, EIF4E EIF4EBP1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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