SCHEMBL29650459

SCHEMBL29650459

CCC(F)(F)CN1CCC(N(C)c2ncc3nc(C)n(CCOc4ccc(Cl)cc4-c4ccnc5c(C(=O)O)csc45)c(=O)c3c2C#N)CC1

nearest known ligand 0.92

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.92

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29650535 0.95 EIF4EBP1 (0.94) EIF4EBP1
SCHEMBL29650473 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650413 0.84 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650474 0.83 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866435 0.83 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650511 0.83 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650421 0.83 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL24071032 0.82 EIF4EBP1 (0.87) EIF4EBP1
SCHEMBL31668383 0.82 EIF4EBP1 (0.87) EIF4EBP1
SCHEMBL29650580 0.82 EIF4EBP1 (0.93) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3993875-A1 METHODS OF TREATING BRAF-MUTATED CANCER CELLS EFFECTOR THERAPEUTICS, INC. (US) 2022-05-11 — — EP disclosed
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