Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.51 |
| ▸ | PRKDC | P78527 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | YES1 | P07947 | 2/20 | 0.47 |
| ▸ | FGR | P09769 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2966913 | 0.89 | RET (0.60) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2959065 | 0.81 | SRC (0.60) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2967660 | 0.78 | IGF1R (0.55) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2960985 | 0.78 | IGF1R (0.68) | IGF1REGFRERBB2SRC | |
| SCHEMBL2965908 | 0.76 | IGF1R (0.71) | IGF1REGFRERBB2 | |
| SCHEMBL2967567 | 0.76 | IGF1R (0.54) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2967840 | 0.76 | IGF1R (0.58) | IGF1REGFRERBB2FYN | |
| SCHEMBL2958098 | 0.75 | IGF1R (0.69) | IGF1REGFRERBB2 | |
| SCHEMBL2967474 | 0.75 | IGF1R (0.76) | IGF1REGFRERBB2 | |
| SCHEMBL2958786 | 0.73 | IGF1R (0.68) | IGF1REGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-B1 | PROTEIN KINASE INHIBITORS | ABBVIE INC (US) | 2015-06-10 | — | — | EP | claimed |
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | claimed |
| EP-1973917-B1 | PROTEIN KINASE INHIBITORS | ABBVIE INC (US) | 2015-06-10 | — | — | EP | disclosed |
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | ABBVIE INC. | 2007-08-30 | — | — | US | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | PIK3CD 264/4885PRKDC 11/4885PIK3CA 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.