Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 12/20 | 0.80 |
| ▸ | KDR | P35968 | 9/20 | 0.76 |
| ▸ | RET | P07949 | 6/20 | 0.76 |
| ▸ | KIF5B | P33176 | 5/20 | 0.76 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.71 |
| ▸ | GAK | O14976 | 2/20 | 0.71 |
| ▸ | STK10 | O94804 | 1/20 | 0.71 |
| ▸ | FLT3 | P36888 | 1/20 | 0.71 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.71 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.71 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.71 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.71 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.71 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29711485 | 1.00 | JAK3 (1.00) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL29372372 | 1.00 | JAK3 (1.00) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL5570070 | 0.89 | EGFR (0.85) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL4469673 | 0.88 | JAK3 (0.79) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL6068633 | 0.86 | KDR (0.82) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL5865262 | 0.86 | EGFR (0.81) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL30925305 | 0.86 | JAK3 (1.00) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL323445 | 0.86 | JAK3 (1.00) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL5864546 | 0.85 | KDR (0.82) | JAK3ABCG2ABCB1EGFRKDR | |
| SCHEMBL5864719 | 0.85 | KDR (0.82) | JAK3ABCG2ABCB1EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2297 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026107237-A1 | RAS AND EGFR INHIBITORS COMBINATION THERAPY | ERASCA, INC. (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260097028-A1 | Methods of Treating Myeloproliferative Neoplasms | KARTOS THERAPEUTICS INC (US) | 2026-04-09 | — | — | US | claimed |
| EP-4629993-A1 | METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS | Kartos Therapeutics (US) | 2025-10-15 | — | — | EP | claimed |
| US-20250295611-A1 | METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS | TESSELLATE THERAPEUTICS INC (US) | 2025-09-25 | — | — | US | claimed |
| US-12268681-B2 | Methods of treating myeloproliferative neoplasms | KARTOS THERAPEUTICS, INC. (US) | 2025-04-08 | — | — | US | claimed |
| US-12138490-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-11-12 | — | — | US | claimed |
| WO-2024124240-A1 | METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS | KARTOS THERAPEUTICS (US) | 2024-06-13 | — | — | WO | claimed |
| CN-113786409-B | Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent | 甫康（上海）健康科技有限责任公司 | 2024-04-02 | — | — | CN | claimed |
| WO-2024011307-A1 | PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER | THRYV THERAPEUTICS INC. (CA) | 2024-01-18 | — | — | WO | claimed |
| WO-2023212244-A1 | METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS | TESSELLATE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | claimed |
| EP-1105378-A1 | QUINAZOLINE DERIVATIVES | Parker Hughes Institute (US) | 2001-06-13 | — | — | EP | claimed |
| WO-2001035952-A2 | RADIOSENSITIZATION OF HUMAN GLIOBLASTOMA CELLS BY QUINAZOLINE COMPOUNDS | PARKER HUGUES INSTITUTE (US) | 2001-05-25 | — | — | WO | claimed |
| EP-1091739-A1 | METHOD FOR INHIBITING C-JUN EXPRESSION USING JAK-3 INHIBITORS | Parker Hughes Institute (US) | 2001-04-18 | — | — | EP | claimed |
| EP-1082311-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | Parker Hughes Institute (US) | 2001-03-14 | — | — | EP | claimed |
| US-6177433-B1 | ADMINISTERING A TYROSINE KINASE INHIBITOR | PARKER HUGHES INSTITUTE | 2001-01-23 | — | — | US | claimed |
| WO-2000051587-A2 | JAK-3 INHIBITORS FOR TREATING ALLERGIC DISORDERS | PARKER HUGHES INSTITUTE (US) | 2000-09-08 | — | — | WO | claimed |
| US-6080747-A | FOR THERAPY AND PROPHYLAXIS OF MAST CELL MEDIATED ALLERGIC REACTIONS | HUGHES INSTITUTE (US) | 2000-06-27 | — | — | US | claimed |
| WO-2000010981-A1 | QUINAZOLINE DERIVATIVES | PARKER HUGHES INSTITUTE (US) | 2000-03-02 | — | — | WO | claimed |
| WO-2000000202-A1 | METHOD FOR INHIBITING C-JUN EXPRESSION USING JAK-3 INHIBITORS | PARKER HUGHES INSTITUTE (US) | 2000-01-06 | — | — | WO | claimed |
| WO-1999061428-A1 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INSTITUTE (US) | 1999-12-02 | — | — | WO | claimed |