SCHEMBL29711485

SCHEMBL29711485

COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK3 P52333 3/20 1.00
▸ ABCG2 Q9UNQ0 3/20 1.00
▸ ABCB1 P08183 1/20 1.00
▸ EGFR P00533 12/20 0.80
▸ KDR P35968 9/20 0.76
▸ RET P07949 6/20 0.76
▸ KIF5B P33176 5/20 0.76
▸ MKNK1 Q9BUB5 2/20 0.76
▸ RIPK2 O43353 2/20 0.71
▸ GAK O14976 2/20 0.71
▸ STK10 O94804 1/20 0.71
▸ FLT3 P36888 1/20 0.71
▸ AAK1 Q2M2I8 1/20 0.71
▸ Q6ZSR9 Q6ZSR9 1/20 0.71
▸ SLK Q9H2G2 1/20 0.71
▸ IRAK4 Q9NWZ3 1/20 0.71
▸ RPS6KA6 Q9UK32 1/20 0.71
▸ ALK Q9UM73 1/20 0.71
▸ NOD1 Q9Y239 2/20 0.71
▸ CLK1 P49759 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372372 1.00 JAK3 (1.00) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL29651 1.00 JAK3 (1.00) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL5570070 0.89 EGFR (0.85) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL4469673 0.88 JAK3 (0.79) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL6068633 0.86 KDR (0.82) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL5865262 0.86 EGFR (0.81) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL323445 0.86 JAK3 (1.00) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL30925305 0.86 JAK3 (1.00) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL5864546 0.85 KDR (0.82) JAK3ABCG2ABCB1EGFRKDR
SCHEMBL20812874 0.85 EGFR (0.80) JAK3ABCG2ABCB1EGFRKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023286088-A1 METHODS AND COMPOSITIONS FOR VIRAL VECTOR TRANSDUCTION Indian Institute Of Science Education And Research Bhopal (IN) 2023-01-19 — — WO claimed
US-20260097102-A1 Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors REGENERON PHARMA (US) 2026-04-09 — — US disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 — — EP disclosed
US-12472241-B2 Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors REGENERON PHARMACEUTICALS, INC. (US) 2025-11-18 — — US disclosed
EP-4629993-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS Kartos Therapeutics (US) 2025-10-15 — — EP disclosed
EP-3782649-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2025-05-14 — — EP disclosed
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 — — WO disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 — — WO disclosed
WO-2024124240-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS KARTOS THERAPEUTICS (US) 2024-06-13 — — WO disclosed
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 — — US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 — — US disclosed
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2023-04-20 — — US disclosed
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels ASCENDIS PHARMA A/S (DE) 2023-01-24 — — US disclosed
WO-2023286088-A1 METHODS AND COMPOSITIONS FOR VIRAL VECTOR TRANSDUCTION Indian Institute Of Science Education And Research Bhopal (IN) 2023-01-19 — — WO disclosed
WO-2023286088-A1 METHODS AND COMPOSITIONS FOR VIRAL VECTOR TRANSDUCTION Indian Institute Of Science Education And Research Bhopal (IN) 2023-01-19 — — WO disclosed
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230123784-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 JAK3 513/4885ABCG2 117/4885ABCB1 1197/4885
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 JAK3 4492/4885ABCG2 21/4885ABCB1 5/4885
US-11559482-B2 Biodegradable polyethylene glycol based water-insoluble hydrogels PLG, PHYKPL, PLOD3 JAK3 513/4885ABCG2 117/4885ABCB1 1197/4885
US-20260097102-A1 Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors ALOX15, ALOX15B, ALOX5 JAK3 4054/4885ABCG2 2563/4885ABCB1 1211/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 JAK3 4492/4885ABCG2 21/4885ABCB1 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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