Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744003 | 1.00 | RPS6KA5 (0.37) | RPS6KA5RPS6KA4HCRTR2MAPTHCRTR1 | |
| SCHEMBL29650996 | 0.77 | HCRTR2 (0.40) | RPS6KA5RPS6KA4HCRTR2MAPTHCRTR1 | |
| SCHEMBL28743609 | 0.77 | HCRTR2 (0.40) | RPS6KA5RPS6KA4HCRTR2MAPTHCRTR1 | |
| SCHEMBL28744131 | 0.76 | HCRTR2 (0.39) | RPS6KA5RPS6KA4HCRTR2MAPTHCRTR1 | |
| SCHEMBL29651173 | 0.76 | HCRTR2 (0.39) | RPS6KA5RPS6KA4HCRTR2MAPTHCRTR1 | |
| SCHEMBL31378032 | 0.75 | HCRTR2 (0.39) | RPS6KA5RPS6KA4HCRTR2HCRTR1ROCK1 | |
| SCHEMBL28743599 | 0.75 | HCRTR2 (0.39) | RPS6KA5RPS6KA4HCRTR2HCRTR1ROCK1 | |
| SCHEMBL29651281 | 0.74 | HCRTR2 (0.38) | RPS6KA5RPS6KA4HCRTR2HCRTR1ROCK1 | |
| SCHEMBL29651283 | 0.74 | HCRTR2 (0.38) | RPS6KA5RPS6KA4HCRTR2HCRTR1ROCK1 | |
| SCHEMBL29650901 | 0.71 | HCRTR2 (0.38) | RPS6KA5RPS6KA4HCRTR2HCRTR1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |