Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.34 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29651281 | 1.00 | HCRTR2 (0.38) | HCRTR2HDAC4HDAC7HDAC5HCRTR1 | |
| SCHEMBL29650996 | 0.87 | HCRTR2 (0.40) | HCRTR2HCRTR1RPS6KA5RPS6KA4ABL1 | |
| SCHEMBL28743609 | 0.87 | HCRTR2 (0.40) | HCRTR2HCRTR1RPS6KA5RPS6KA4ABL1 | |
| SCHEMBL29650901 | 0.87 | HCRTR2 (0.38) | HCRTR2HCRTR1RPS6KA5RPS6KA4ABL1 | |
| SCHEMBL28744131 | 0.86 | HCRTR2 (0.39) | HCRTR2HCRTR1RPS6KA5RPS6KA4ABL1 | |
| SCHEMBL29651173 | 0.86 | HCRTR2 (0.39) | HCRTR2HCRTR1RPS6KA5RPS6KA4ABL1 | |
| SCHEMBL31378032 | 0.85 | HCRTR2 (0.39) | HCRTR2HCRTR1RPS6KA5RPS6KA4ROCK1 | |
| SCHEMBL28743599 | 0.85 | HCRTR2 (0.39) | HCRTR2HCRTR1RPS6KA5RPS6KA4ROCK1 | |
| SCHEMBL29651278 | 0.74 | RPS6KA5 (0.37) | HCRTR2HCRTR1RPS6KA5RPS6KA4ROCK1 | |
| SCHEMBL28744003 | 0.74 | RPS6KA5 (0.37) | HCRTR2HCRTR1RPS6KA5RPS6KA4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |