Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 5/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456772 | 1.00 | CKS1B (0.52) | CKS1BSKP1SKP2DRD2CTSK | |
| SCHEMBL29652934 | 0.94 | PIM1 (0.49) | CKS1BSKP1SKP2CTSKKDM4D | |
| SCHEMBL29652975 | 0.94 | PIM1 (0.49) | CKS1BSKP1SKP2CTSKKDM4D | |
| SCHEMBL24456502 | 0.94 | PIM1 (0.49) | CKS1BSKP1SKP2CTSKKDM4D | |
| SCHEMBL29653231 | 0.89 | PDE10A (0.43) | CKS1BSKP1SKP2DRD2CTSK | |
| SCHEMBL13156552 | 0.86 | CKS1B (0.52) | CKS1BSKP1SKP2DRD2CTSK | |
| SCHEMBL24456395 | 0.84 | CKS1B (0.46) | CKS1BSKP1SKP2 | |
| SCHEMBL21056786 | 0.83 | CKS1B (0.53) | CKS1BSKP1SKP2DRD2CTSK | |
| SCHEMBL16522585 | 0.82 | MAP4K4 (0.51) | CKS1BSKP1SKP2DRD2KDM4D | |
| SCHEMBL15770317 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2DRD2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |