Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456502 | 0.91 | PIM1 (0.49) | PDE10ACTSKKDM4DCKS1BSKP1 | |
| SCHEMBL29652934 | 0.91 | PIM1 (0.49) | PDE10ACTSKKDM4DCKS1BSKP1 | |
| SCHEMBL29652975 | 0.91 | PIM1 (0.49) | PDE10ACTSKKDM4DCKS1BSKP1 | |
| SCHEMBL29653444 | 0.89 | CKS1B (0.52) | PDE10ACTSKKDM4DCKS1BSKP1 | |
| SCHEMBL24456772 | 0.89 | CKS1B (0.52) | PDE10ACTSKKDM4DCKS1BSKP1 | |
| SCHEMBL15109521 | 0.81 | MAP4K4 (0.44) | PDE10AEPHX2KDM4DCKS1BSKP1 | |
| SCHEMBL13457022 | 0.81 | MAP4K4 (0.44) | PDE10AEPHX2KDM4DCKS1BSKP1 | |
| SCHEMBL4119084 | 0.79 | MAP4K4 (0.41) | PDE10AEPHX2KDM4DCKS1BSKP1 | |
| SCHEMBL4132744 | 0.79 | MAP4K4 (0.41) | PDE10AEPHX2KDM4DCKS1BSKP1 | |
| SCHEMBL21847896 | 0.78 | GPR119 (0.55) | PDE10AEPHX2KDM4DCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |