Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495057 | 0.84 | KDM4E (0.40) | LIMK1PARP1KDM4EJAK2JAK1 | |
| SCHEMBL23514475 | 0.79 | KDM4E (0.46) | KDM4EJAK2JAK1TYK2JAK3 | |
| SCHEMBL4603472 | 0.73 | LIMK1 (0.44) | LIMK1PARP1IKBKBCHUKL3MBTL1 | |
| SCHEMBL4072413 | 0.72 | PRMT5 (0.42) | LIMK1KDM4EHTTSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4603416 | 0.71 | LIMK1 (0.43) | LIMK1PARP1IKBKBCHUKKDM4E | |
| SCHEMBL21139553 | 0.70 | KDM4E (0.39) | KDM4EHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL19554538 | 0.69 | LIMK1 (0.51) | LIMK1PARP1IKBKBCHUKKDM4E | |
| SCHEMBL30001410 | 0.69 | PARP1 (0.53) | LIMK1PARP1IKBKBCHUKKDM4E | |
| SCHEMBL23495082 | 0.68 | KDM4E (0.38) | KDM4EHTTSMN1; SMN2L3MBTL1EGFR | |
| SCHEMBL4069439 | 0.68 | HSP90AA1 (0.43) | KDM4EHTTSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110494434-B | Pyrazolophenyl compounds, compositions thereof, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-05-24 | — | — | CN | disclosed |