Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23413589 | 0.84 | ALDH1A1 (0.47) | PARP1KDM4EMMP2TSHRCYP3A4 | |
| SCHEMBL23413127 | 0.79 | ALOX15 (0.47) | PARP1KDM4ETSHRALOX15MAPT | |
| SCHEMBL30122238 | 0.72 | LIMK1 (0.51) | PARP1LIMK1IKBKBCHUKKDM4E | |
| SCHEMBL5187759 | 0.71 | LIMK1 (0.46) | PARP1LIMK1IKBKBCHUKKDM4E | |
| SCHEMBL29959688 | 0.69 | PARP1 (1.00) | PARP1KDM4EMMP2TSHRLMNA | |
| SCHEMBL460456 | 0.69 | PARP1 (1.00) | PARP1KDM4EMMP2TSHRLMNA | |
| SCHEMBL29923346 | 0.69 | PARP1 (1.00) | PARP1KDM4EMMP2TSHRLMNA | |
| SCHEMBL29654023 | 0.69 | LIMK1 (0.51) | PARP1LIMK1IKBKBCHUKKDM4E | |
| SCHEMBL19555042 | 0.69 | PARP1 (0.53) | PARP1LIMK1IKBKBCHUKKDM4E | |
| SCHEMBL30844941 | 0.69 | PARP1 (0.53) | PARP1LIMK1IKBKBCHUKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |