Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.51 |
| ▸ | OGFRL1 | Q5TC84 | 9/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL2968843 | 0.91 | OPRM1 (0.45) | OPRM1OGFRL1OPRL1DRD2DRD3 | |
| SCHEMBL2965466 | 0.84 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1DRD2DRD3 | |
| SCHEMBL2970325 | 0.83 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Citric Acid SCHEMBL2968844 | 0.78 | OPRM1 (0.48) | OPRM1OGFRL1OPRL1DRD2DRD3 | |
| Citric Acid SCHEMBL2976654 | 0.75 | OPRM1 (0.48) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2976491 | 0.70 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1DRD2DRD3 | |
| SCHEMBL2971719 | 0.69 | OPRM1 (0.57) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL682592 | 0.68 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL681581 | 0.68 | OPRM1 (0.75) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL1304030 | 0.68 | OPRM1 (1.00) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776848-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | PKD1, PKD2, NR3C2 | OPRM1 768/4885OGFRL1 1860/4885OPRL1 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.