Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540616 | 1.00 | CFTR (0.56) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL23556347 | 0.85 | ALPL (0.46) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL29476152 | 0.85 | SLC6A4 (0.56) | CFTRKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL23540082 | 0.85 | SLC6A4 (0.56) | CFTRKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL23539893 | 0.84 | ABL1 (0.48) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL29476388 | 0.84 | ABL1 (0.48) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL23539858 | 0.83 | TTR (0.55) | CFTRKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL29476378 | 0.82 | CFTR (0.56) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL23539751 | 0.82 | CFTR (0.56) | CFTRALPLKDM4EALDH1A1MAPT | |
| SCHEMBL23539577 | 0.81 | ALPL (0.43) | CFTRALPLKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |