Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 5/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5952352 | 1.00 | BACE1 (0.53) | BACE1MEN1KMT2ATDP1PTPRC | |
| SCHEMBL29655190 | 1.00 | BACE1 (0.53) | BACE1MEN1KMT2ATDP1PTPRC | |
| Ammonia Solution, Strong SCHEMBL5953223 | 0.98 | BACE1 (0.51) | BACE1MEN1KMT2ATDP1PTPRC | |
| SCHEMBL15250336 | 0.88 | BACE1 (0.53) | BACE1TDP1PTPRCPTPN1MAP4K4 | |
| SCHEMBL29655217 | 0.84 | MEN1 (0.48) | BACE1MEN1KMT2ATDP1PTPRC | |
| SCHEMBL23040370 | 0.82 | TNKS (0.49) | BACE1TDP1PTPRCPTPN1MAP4K4 | |
| SCHEMBL5843391 | 0.82 | ALOX15 (0.57) | BACE1MEN1KMT2APTPRCPTPN1 | |
| SCHEMBL29878768 | 0.82 | ALOX15 (0.57) | BACE1MEN1KMT2APTPRCPTPN1 | |
| SCHEMBL5556308 | 0.80 | MEN1 (0.59) | MEN1KMT2ATDP1FEN1ALOX5AP | |
| SCHEMBL28602582 | 0.80 | BACE1 (0.46) | BACE1PTPRCPTPN1MAP4K4FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |