Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23361548 | 0.96 | NR1H2 (0.49) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL16993007 | 0.90 | NR1H2 (0.51) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL24027370 | 0.84 | NR1H2 (0.48) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL29655421 | 0.82 | NR1H2 (0.50) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL16993145 | 0.82 | NR1H2 (0.47) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL28891296 | 0.82 | GPR119 (0.46) | JAK2JAK1USP30USP2SMN1; SMN2 | |
| SCHEMBL21494393 | 0.81 | NR1H2 (0.46) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL14697592 | 0.80 | NR1H2 (0.50) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL15108637 | 0.80 | NR1H2 (0.44) | NR1H2DDB1CRBNJAK2JAK1 | |
| SCHEMBL19997025 | 0.80 | NR1H2 (0.44) | NR1H2DDB1CRBNJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058457-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS | Ildong Pharmaceutical Co., Ltd. (KR) | 2022-09-21 | — | — | EP | disclosed |
| WO-2022096930-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-05-12 | — | — | WO | disclosed |