Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655711 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2TAS1R3TAS1R1CYP26A1CYP26B1 | |
| SCHEMBL29696137 | 0.85 | CYP26A1 (0.47) | SMN1; SMN2CYP26A1CYP26B1PTGER4RARA | |
| SCHEMBL30353262 | 0.80 | KDM4E (0.54) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL25029929 | 0.80 | PTGER4 (0.58) | TAS1R3TAS1R1CYP26A1CYP26B1PTGER4 | |
| SCHEMBL30181635 | 0.80 | PTGER4 (0.58) | TAS1R3TAS1R1CYP26A1CYP26B1PTGER4 | |
| SCHEMBL25029928 | 0.80 | PTGER4 (0.58) | TAS1R3TAS1R1CYP26A1CYP26B1PTGER4 | |
| SCHEMBL29655717 | 0.80 | NPC1 (0.61) | SMN1; SMN2PTGER4GAANPC1RAB9A | |
| SCHEMBL29655774 | 0.79 | NPC1 (0.56) | SMN1; SMN2PTGER4GAANPC1RAB9A | |
| SCHEMBL30353220 | 0.79 | RARA (0.54) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL28347731 | 0.79 | RARA (0.54) | CYP26A1CYP26B1RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |