Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27575677 | 0.87 | TSHR (0.54) | TDP1ALDH1A1TSHRFBP1ACHE | |
| SCHEMBL4142462 | 0.82 | TDP1 (0.75) | TDP1ALDH1A1MAOBHSD17B10NPC1 | |
| SCHEMBL8051514 | 0.81 | ALDH1A1 (0.67) | TDP1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL2954856 | 0.80 | ALDH1A1 (0.71) | TDP1ALDH1A1TSHRACHEMAOB | |
| SCHEMBL23282563 | 0.79 | ALDH1A1 (0.65) | TDP1ALDH1A1MAOBHSD17B10NPC1 | |
| SCHEMBL10711666 | 0.79 | ALDH1A1 (0.65) | TDP1ALDH1A1TSHRHSD17B10NPC1 | |
| SCHEMBL2326639 | 0.79 | TDP1 (0.65) | TDP1ALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL2332272 | 0.79 | TDP1 (0.65) | TDP1ALDH1A1FBP1HSD17B10NPC1 | |
| SCHEMBL2331528 | 0.79 | ALDH1A1 (0.65) | TDP1ALDH1A1MAOBHSD17B10NPC1 | |
| SCHEMBL29475327 | 0.79 | ALDH1A1 (0.65) | TDP1ALDH1A1MAOBHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104230719-B | A kind of method preparing substituted biphenyl | HUAZHONG NORMAL UNIVERSITY (CN) | 2016-04-13 | — | — | CN | disclosed |
| CN-104230719-A | Method for preparing substituted biphenyl | UNIV HUAZHONG NORMAL | 2014-12-24 | — | — | CN | disclosed |
| US-7772446-B2 | Method for producing substituted biphenyls | BASF SE (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1856024-B1 | METHOD FOR PRODUCING SUBSTITUTED BIPHENYLS | BASF SE (DE) | 2008-08-06 | — | — | EP | disclosed |
| US-20080183021-A1 | Method for Producing Substituted Biphenyls | BASF SE (DE) | 2008-07-31 | — | — | US | disclosed |
| EP-1856024-A1 | METHOD FOR PRODUCING SUBSTITUTED BIPHENYLS | BASF AKTIENGESELLSCHAFT (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092429-A1 | METHOD FOR PRODUCING SUBSTITUTED BIPHENYLS | BASF AKTIENGESELLSCAHFT (DE) | 2006-09-08 | — | — | WO | disclosed |
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| US-6362380-B1 | REACTING 2-NITROCHLOROBENZENE AND A BORONIC ACID ; PALLADIUM CATALYST | BASF AKTIENGESELLSCHAFT (DE) | 2002-03-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| EP-0888261-B1 | PROCESS FOR PREPARING NITROBIPHENYLENE | BASF AG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |
| EP-0888261-A1 | PROCESS FOR PREPARING NITROBIPHENYLENE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997033846-A1 | PROCESS FOR PREPARING NITROBIPHENYLENE | BASF AKTIENGESELLSCHAFT (DE) | 1997-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080183021-A1 | Method for Producing Substituted Biphenyls | CBR3, DDT, HRH3 | TDP1 1458/4885ALDH1A1 2309/4885TSHR 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.