Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | LPO | P22079 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154948 | 0.97 | FDPS (0.48) | FDPSLPOKMT2AMEN1CNR2 | |
| Bromide SCHEMBL27242084 | 0.89 | FDPS (0.43) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL7166348 | 0.88 | FDPS (0.46) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL2398203 | 0.88 | FDPS (0.46) | FDPSLPOKMT2AMEN1CNR2 | |
| Bromide SCHEMBL28245379 | 0.87 | FDPS (0.42) | FDPSLPOKMT2AMEN1CNR2 | |
| Water SCHEMBL29120398 | 0.86 | FDPS (0.44) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL2395476 | 0.86 | FDPS (0.44) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL2393253 | 0.86 | FDPS (0.44) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL7152443 | 0.86 | FDPS (0.44) | FDPSLPOKMT2AMEN1CNR2 | |
| SCHEMBL2399728 | 0.86 | FDPS (0.44) | FDPSLPOKMT2AMEN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114471720-A | Organometallic catalysts and their use | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | disclosed |