Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 16/20 | 0.53 |
| ▸ | ARG2 | P78540 | 15/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10006227 | 1.00 | ARG1 (0.53) | ARG1ARG2SIGMAR1OPRM1TMEM97 | |
| SCHEMBL18079490 | 0.93 | ARG1 (0.44) | ARG1ARG2SIGMAR1OPRM1TMEM97 | |
| SCHEMBL20683472 | 0.88 | ARG1 (0.64) | ARG1ARG2 | |
| SCHEMBL18079470 | 0.88 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL18079466 | 0.84 | ARG1 (0.54) | ARG1ARG2 | |
| SCHEMBL10006164 | 0.84 | ARG1 (0.52) | ARG1ARG2SIGMAR1 | |
| SCHEMBL10006212 | 0.83 | ARG1 (0.53) | ARG1ARG2SIGMAR1TMEM97ACHE | |
| SCHEMBL10006166 | 0.83 | ARG1 (0.55) | ARG1ARG2 | |
| SCHEMBL10006216 | 0.81 | ARG1 (0.51) | ARG1ARG2 | |
| SCHEMBL29657567 | 0.81 | ARG1 (0.51) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283332-A1 | USES OF ARGINASE INHIBITORS FOR MANAGING KIDNEY DISEASE AND CARDIOVASCULAR CONDITIONS | EMORY UNIVERSITY (US) | 2023-01-12 | — | — | WO | disclosed |
| CN-110123820-B | Arginase inhibitors and methods of use thereof | 阿斯利康公司 | 2022-05-31 | — | — | CN | disclosed |