SCHEMBL29658013

SCHEMBL29658013

Brc1c2ccccc2c(-c2ccc(-c3cccc4ccccc34)cc2)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
CA12 O43570 3/20 0.47
CA1 P00915 3/20 0.47
CA2 P00918 3/20 0.47
CA9 Q16790 3/20 0.47
ENPP3 O14638 1/20 0.44
ENPP1 P22413 1/20 0.44
PPARG P37231 9/20 0.41
PPARA Q07869 9/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
PPARD Q03181 1/20 0.41
MCL1 Q07820 1/20 0.41
ACMSD Q8TDX5 1/20 0.41
CYP1A2 P05177 1/20 0.40
TNF P01375 1/20 0.40
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA7 P36544 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2252435 1.00 HDAC8 (0.50) HDAC8HDAC6CA12CA1CA2
SCHEMBL29658012 1.00 HDAC8 (0.50) HDAC8HDAC6CA12CA1CA2
SCHEMBL16657337 0.91 HDAC8 (0.47) HDAC8HDAC6CA12CA1CA2
SCHEMBL24446252 0.90 CA12 (0.55) HDAC8HDAC6CA12CA1CA2
SCHEMBL28491556 0.89 HDAC8 (0.50) HDAC8HDAC6CA12CA1CA2
SCHEMBL20622904 0.87 HDAC8 (0.41) HDAC8HDAC6CA12CA1CA2
SCHEMBL25625173 0.87 MCL1 (0.44) HDAC8HDAC6CA12CA1CA2
SCHEMBL25625218 0.87 MCL1 (0.44) HDAC8HDAC6CA12CA1CA2
SCHEMBL29995332 0.86 TNF (0.52) HDAC8HDAC6CA12CA1CA2
SCHEMBL16105349 0.86 TNF (0.52) HDAC8HDAC6CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4048675-B1 COMPOUNDS THAT CAN BE USED IN AN ORGANIC ELECTRONIC DEVICE MERCK PATENT GMBH (DE) 2026-04-08 EP disclosed
EP-4048675-A1 COMPOUNDS THAT CAN BE USED IN AN ORGANIC ELECTRONIC DEVICE Merck Patent GmbH (DE) 2022-08-31 EP disclosed
CN-114630831-A Compounds useful in organic electronic devices 默克专利有限公司 2022-06-14 CN disclosed