Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9235253 | 1.00 | CYP3A4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL10772992 | 1.00 | CYP3A4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL7890326 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL30275019 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1287 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL11150424 | 1.00 | CYP3A4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL23879391 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL1836319 | 0.82 | — | — | |
| Ammonia Solution, Strong SCHEMBL162701 | 0.82 | — | — | |
| Phosphine SCHEMBL1943937 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288130-B2 | Polypeptide cleavage process | MEDTRONIC, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20100311947-A1 | POLYPEPTIDE CLEAVAGE PROCESS | MEDTRONIC, INC. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7771966-B2 | Polypeptide cleavage process | MEDTRONIC, INC. (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1532142-A4 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN INC (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20050227313-A1 | Polypeptide cleavage process | MEDTRONIC, INC. | 2005-10-13 | — | — | US | disclosed |
| EP-1532142-A2 | POLYPEPTIDE CLEAVAGE PROCESS | Restoragen, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003100015-A2 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN, INC. (US) | 2003-12-04 | — | — | WO | disclosed |