Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29663254 | 0.87 | FADS1 (0.40) | KDM5BSYKPIK3CDPIK3R2PIK3CG | |
| SCHEMBL29663420 | 0.87 | KDM5B (0.43) | KDM5BSYKPIK3CDPIK3CG | |
| SCHEMBL29663430 | 0.84 | KDM5B (0.43) | KDM5BSYKPIK3CDPIK3CGBRD4 | |
| SCHEMBL29662997 | 0.84 | PDK2 (0.38) | KDM5BPIK3CDPIK3R2PIK3CGJAK2 | |
| SCHEMBL29663507 | 0.79 | KDM5A (0.34) | KDM5BPIK3CDPIK3R2PIK3CGBRD4 | |
| SCHEMBL29663208 | 0.74 | CREBBP (0.47) | PIK3CDBRD4CREBBP | |
| SCHEMBL29663428 | 0.74 | KDM5B (0.40) | KDM5BPRMT5WDR77SYKNAMPT | |
| SCHEMBL29663303 | 0.74 | KDM5B (0.38) | KDM5BPRMT5WDR77SYKNAMPT | |
| SCHEMBL29663510 | 0.70 | JMJD6 (0.34) | KDM5BPIK3CDBRD4 | |
| SCHEMBL29663145 | 0.70 | PIK3CD (0.35) | PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999183-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | Ono Pharmaceutical Co., Ltd. (JP) | 2022-05-25 | — | — | EP | disclosed |