Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 6/20 | 0.55 |
| ▸ | TACR2 | P21452 | 3/20 | 0.55 |
| ▸ | TACR1 | P25103 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296503 | 0.94 | TACR3 (0.63) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL296864 | 0.93 | TACR3 (0.55) | TACR3TACR2TACR1CCR1SFRP1 | |
| SCHEMBL296043 | 0.92 | TACR3 (0.51) | TACR3TACR2TACR1KCNH2CCR1 | |
| SCHEMBL296922 | 0.92 | TACR3 (0.66) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL297619 | 0.92 | TACR3 (0.56) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL296643 | 0.89 | TACR3 (0.59) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL295924 | 0.86 | TACR3 (0.75) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL297869 | 0.86 | TACR3 (0.64) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL3271085 | 0.85 | TACR3 (0.74) | TACR3TACR2TACR1KCNH2GPR119 | |
| SCHEMBL296792 | 0.85 | TACR3 (0.67) | TACR3TACR2TACR1KCNH2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200982-B1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-03-14 | — | — | EP | disclosed |
| US-20110021565-A1 | PIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | KNUST HENNER | 2011-01-27 | — | — | US | disclosed |
| US-20090076081-A1 | PIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076081-A1 | PIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | DRD2, DRD3, OPRL1 | TACR3 95/4885TACR2 21/4885TACR1 26/4885 |
| US-20110021565-A1 | PIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | DRD2, DRD3, OPRL1 | TACR3 95/4885TACR2 21/4885TACR1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.