Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 7/20 | 0.42 |
| ▸ | F2 | P00734 | 7/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15891771 | 0.80 | CXCR2 (0.53) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL29664611 | 0.79 | F2 (0.42) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL5899540 | 0.77 | CXCR2 (0.42) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL5899514 | 0.77 | CXCR2 (0.42) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL12721154 | 0.76 | PREP (0.48) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL15890142 | 0.76 | CXCR2 (0.49) | CXCR2PREPPSMB5PSEN1PSEN2 | |
| SCHEMBL13197066 | 0.73 | CXCR2 (0.51) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL21012782 | 0.73 | CXCR2 (0.40) | CXCR2PREPF2PRSS1PSMB5 | |
| SCHEMBL16075596 | 0.72 | CXCR2 (0.42) | CXCR2PREPF2PSMB5 | |
| SCHEMBL22080961 | 0.71 | PREP (0.40) | CXCR2PREPF2PSMB5PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251630-A1 | SULFONYL UREA NLRP3 INFLAMMASOME INHIBITORS | Venatorx Pharmaceuticals, Inc. (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022115417-A1 | SULFONYL UREA NLRP3 INFLAMMASOME INHIBITORS | VenatoRx Pharmaceuticals, Inc. (US) | 2022-06-02 | — | — | WO | disclosed |