Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 4/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960965 | 1.00 | CXCR2 (0.42) | CXCR2PREPEGFRF2PSMB5 | |
| SCHEMBL19228921 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL12721154 | 0.73 | PREP (0.48) | CXCR2PREPF2PSMB5 | |
| SCHEMBL15780083 | 0.73 | CXCR2 (0.51) | CXCR2PREPEGFRF2PSMB5 | |
| SCHEMBL21012782 | 0.72 | CXCR2 (0.40) | CXCR2PREPF2PSMB5 | |
| SCHEMBL5899730 | 0.71 | PREP (0.40) | CXCR2PREPEGFRF2PSMB5 | |
| SCHEMBL30728958 | 0.71 | KDM4E (0.44) | — | |
| SCHEMBL1068456 | 0.71 | KDM4E (0.44) | — | |
| SCHEMBL30774154 | 0.71 | KDM4E (0.44) | — | |
| SCHEMBL18589064 | 0.71 | PREP (0.41) | CXCR2PREPEGFRF2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224712-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | UNIV DUKE (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170224712-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | UNIV DUKE (US) | 2017-08-10 | — | — | US | disclosed |
| US-9526740-B2 | Prochelators as broad-spectrum antimicrobial agents and methods of use | DUKE UNIVERSITY (US) | 2016-12-27 | — | — | US | disclosed |
| US-9526740-B2 | Prochelators as broad-spectrum antimicrobial agents and methods of use | DUKE UNIVERSITY (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160220592-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | UNIV DUKE (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160220592-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | UNIV DUKE (US) | 2016-08-04 | — | — | US | disclosed |
| US-9333213-B2 | Prochelators as broad-spectrum antimicrobial agents and methods of use | DUKE UNIVERSITY (US) | 2016-05-10 | — | — | US | disclosed |
| US-9333213-B2 | Prochelators as broad-spectrum antimicrobial agents and methods of use | DUKE UNIVERSITY (US) | 2016-05-10 | — | — | US | disclosed |
| US-20140274955-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | DUKE UNIVERSITY (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140274955-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | DUKE UNIVERSITY (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160220592-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | CLPP, MPO, PSAP | CXCR2 1625/4885PREP 25/4885EGFR 4862/4885 |
| US-20170224712-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | CLPP, MPO, PSAP | CXCR2 1625/4885PREP 25/4885EGFR 4862/4885 |
| US-20140274955-A1 | PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE | CLPP, MPO, PSAP | CXCR2 1625/4885PREP 25/4885EGFR 4862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.