Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24478445 | 0.99 | KIT (0.42) | KITMAP3K11PDGFRBPDGFRAFYN | |
| SCHEMBL24478653 | 0.83 | FYN (0.46) | KITMAP3K11PDGFRBPDGFRAFYN | |
| Hydrochloric Acid SCHEMBL29665260 | 0.82 | FYN (0.45) | KITMAP3K11PDGFRBPDGFRAFYN | |
| Hydrochloric Acid SCHEMBL29665261 | 0.81 | FYN (0.44) | KITMAP3K11PDGFRBPDGFRAFYN | |
| SCHEMBL24478459 | 0.75 | PDE10A (0.34) | KITJAK2JAK1TYK2KDR | |
| SCHEMBL22714762 | 0.74 | KIT (0.43) | KITMAP3K11PDGFRBPDGFRAFYN | |
| SCHEMBL30885087 | 0.74 | KIT (0.43) | KITMAP3K11PDGFRBPDGFRAFYN | |
| SCHEMBL29481398 | 0.73 | KMT2A (0.42) | KITMAP3K11PDGFRBPDGFRAFYN | |
| SCHEMBL29665301 | 0.73 | PIK3CD (0.44) | KDM4E | |
| SCHEMBL30569745 | 0.72 | PDGFRB (0.47) | KITPDGFRBPDGFRAFYNTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251617-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112491-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-02 | — | — | WO | disclosed |