SCHEMBL29669016

SCHEMBL29669016

O=S(=O)(Nc1cccc(F)n1)c1cc(Cl)c(NCc2ccccc2CN2CCC2)cc1F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 19/20 1.00
SCN8A Q9UQD0 19/20 1.00
SCN1A P35498 18/20 1.00
SCN9A Q15858 1/20 0.64
SCN1B Q07699 2/20 0.63
NR1I2 O75469 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20237574 1.00 SCN5A (1.00) SCN5ASCN8ASCN1ASCN9ASCN1B
SCHEMBL20237637 0.92 SCN1A (1.00) SCN5ASCN8ASCN1ASCN1BNR1I2
SCHEMBL29669116 0.92 SCN1A (1.00) SCN5ASCN8ASCN1ASCN1BNR1I2
SCHEMBL20237622 0.89 SCN1A (1.00) SCN5ASCN8ASCN1A
SCHEMBL29669134 0.89 SCN1A (1.00) SCN5ASCN8ASCN1A
SCHEMBL29669138 0.88 SCN5A (1.00) SCN5ASCN8ASCN1ASCN9ASCN1B
SCHEMBL20237822 0.88 SCN5A (1.00) SCN5ASCN8ASCN1ASCN9ASCN1B
SCHEMBL29669036 0.85 SCN8A (1.00) SCN5ASCN8ASCN1ASCN1BNR1I2
SCHEMBL20237824 0.85 SCN8A (1.00) SCN5ASCN8ASCN1ASCN1BNR1I2
SCHEMBL29668396 0.84 SCN8A (1.00) SCN5ASCN8ASCN1ASCN1BNR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110325531-B Benzenesulfonamides and their use as therapeutic agents 泽农医药公司 2022-05-27 CN disclosed