SCHEMBL29669552

SCHEMBL29669552

Cc1cc(C)cc([C@@H]2COC(=O)N2)c1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.33
MAOA P21397 1/20 0.33
SLC6A2 P23975 1/20 0.33
MGLL Q99685 3/20 0.33
CYP19A1 P11511 2/20 0.32
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28983091 0.83 CYP19A1 (0.47) MGLLCYP19A1ALOX15ALOX12
SCHEMBL31494783 0.83 CYP19A1 (0.47) MGLLCYP19A1ALOX15ALOX12
SCHEMBL28983095 0.83 CYP19A1 (0.47) MGLLCYP19A1ALOX15ALOX12
SCHEMBL30370372 0.83 CYP19A1 (0.47) MGLLCYP19A1ALOX15ALOX12
SCHEMBL30370325 0.83 CYP19A1 (0.47) MGLLCYP19A1ALOX15ALOX12
SCHEMBL28983087 0.81 CYP19A1 (0.41) CYP19A1
SCHEMBL28983084 0.81 CYP19A1 (0.41) CYP19A1
SCHEMBL5663809 0.78 CYP19A1 (0.40) MGLLCYP19A1
SCHEMBL29669508 0.77 CYP19A1 (0.43) CYP19A1ALOX15ALOX12
SCHEMBL1440721 0.76 TNKS (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114478422-B Intermediate of pregabalin and preparation method thereof 上海医药工业研究院 2024-03-22 CN disclosed
CN-114478422-A Pregabalin intermediate and preparation method thereof 上海医药工业研究院 2022-05-13 CN disclosed