Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.44 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | FECH | P22830 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.43 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21528272 | 1.00 | PIK3CG (0.54) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL30405620 | 0.92 | PIK3CD (0.60) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL21528027 | 0.92 | PIK3CD (0.60) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL20553552 | 0.89 | PIK3CD (0.45) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| Trifluoroacetic Acid SCHEMBL20553551 | 0.89 | PIK3CD (0.56) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| Trifluoroacetic Acid SCHEMBL29669807 | 0.89 | PIK3CD (0.56) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL23157408 | 0.83 | PIK3CD (0.51) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL30405222 | 0.81 | PIK3CD (0.64) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| SCHEMBL20552797 | 0.81 | PIK3CD (0.64) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 | |
| Trifluoroacetic Acid SCHEMBL21528139 | 0.80 | RET (0.54) | PIK3CGPIK3CDPIK3CAFGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11364300-B2 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2022-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11364300-B2 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | MTOR, RICTOR, RPTOR | PIK3CG 120/4885PIK3CD 94/4885PIK3CA 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.