Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23146303 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL29183417 | 0.81 | CYP1A1 (0.49) | ALDH1A1HPGDNPC1CYP1A2HDAC3 | |
| SCHEMBL23146416 | 0.80 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL29670080 | 0.78 | HDAC3 (0.43) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1313937 | 0.78 | HDAC3 (0.43) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22637560 | 0.76 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL1313337 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL3435154 | 0.75 | HDAC6 (0.56) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL23180331 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL25843716 | 0.74 | HDAC3 (0.40) | ALDH1A1HPGDSMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034106-A1 | THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | The Global Alliance for TB Drug Development, Inc. (US) | 2022-08-03 | — | — | EP | disclosed |
| CN-114746089-A | Thiazolecarboxamide compounds and their use for the treatment of mycobacterial infections | 结核病药物开发全球联盟公司 | 2022-07-12 | — | — | CN | disclosed |