Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.37 |
| ▸ | IGF1R | P08069 | 4/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.37 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201536 | 0.75 | SRC (0.47) | MAP4K4EGFRKDM4EMAPK1SRC | |
| SCHEMBL2960099 | 0.74 | SRC (0.55) | MAP4K4EGFRERBB2IGF1RERBB3 | |
| SCHEMBL2965844 | 0.73 | EGFR (0.48) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL2962536 | 0.69 | MAP4K4 (0.41) | MAP4K4MAPK1PIK3CDSRCFGFR2 | |
| SCHEMBL4818639 | 0.69 | SRC (0.59) | MAP4K4EGFRMAPK1SRC | |
| SCHEMBL24096870 | 0.69 | SRC (0.45) | MAP4K4EGFRMAPK1PIK3CDSRC | |
| SCHEMBL4825100 | 0.69 | SRC (0.56) | MAP4K4MAPK1PIK3CDSRCFGFR2 | |
| SCHEMBL24096486 | 0.68 | SRC (0.50) | MAP4K4EGFRALDH1A1KDM4EMAPK1 | |
| SCHEMBL5804464 | 0.68 | BTK (0.60) | MAP4K4EGFRERBB2ERBB4PIK3CD | |
| SCHEMBL2969443 | 0.67 | SRC (0.46) | MAP4K4EGFRKDM4EMAPK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-B1 | PROTEIN KINASE INHIBITORS | ABBVIE INC (US) | 2015-06-10 | — | — | EP | disclosed |
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | ABBVIE INC. | 2007-08-30 | — | — | US | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | HRH3 2957/4885MAP4K4 42/4885ACHE 2313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.