Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1489599 | 1.00 | TDP1 (0.55) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL424471 | 1.00 | TDP1 (0.55) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL697038 | 1.00 | TDP1 (0.55) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| Water SCHEMBL8461991 | 0.98 | TDP1 (0.53) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| Water SCHEMBL9529895 | 0.98 | TDP1 (0.53) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL29733565 | 0.93 | TDP1 (0.48) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL516874 | 0.93 | TDP1 (0.48) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL923829 | 0.93 | TDP1 (0.48) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| Water SCHEMBL4813848 | 0.91 | TDP1 (0.47) | TDP1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL6654554 | 0.83 | TDP1 (0.70) | TDP1ALDH1A1LMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345664-B2 | Process for the preparation of (S)-Netarsudil,its salts and polymorphs | Micro Labs Ltd. (IN) | 2022-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345664-B2 | Process for the preparation of (S)-Netarsudil,its salts and polymorphs | VKORC1L1, CYP3A4, REN | TDP1 375/4885ADRB2 102/4885ADRB1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.