SCHEMBL2967577

SCHEMBL2967577

Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 1.00
CYP2C19 P33261 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2954347 1.00 AR (1.00) ARCYP2C19
SCHEMBL2958856 1.00 AR (1.00) ARCYP2C19
SCHEMBL13216169 1.00 AR (1.00) ARCYP2C19
SCHEMBL29361549 1.00 AR (1.00) ARCYP2C19
SCHEMBL13215941 1.00 AR (1.00) ARCYP2C19
SCHEMBL13199496 0.94 AR (0.88) ARCYP2C19
SCHEMBL13216333 0.94 AR (0.88) ARCYP2C19
SCHEMBL2958161 0.94 AR (0.88) ARCYP2C19
SCHEMBL13199495 0.94 AR (0.88) ARCYP2C19
SCHEMBL13216331 0.94 AR (0.88) ARCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200046734-A1 Methods of Reducing Mammographic Breast Density and/or Breast Cancer Risk HAVAH THERAPEUTICS PTY LTD (AU) 2020-02-13 US claimed
US-10471073-B2 Methods of reducing mammographic breast density and/or breast cancer risk Havah Therapeutics Pty Ltd. (AU) 2019-11-12 US claimed
WO-2016061135-A1 DRUG COMBINATIONS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND METHODS OF MAKING AND USING THEM VICUS THERAPEUTICS, LLC (US) 2016-04-21 WO claimed
US-20140329809-A1 NEW LEUKOCYTE INFILTRATE MARKERS FOR ROSACEA AND USES THEREOF GALDERMA RESEARCH & DEVELOPMENT (FR) 2014-11-06 US claimed
EP-2771484-A1 NEW LEUKOCYTE INFILTRATE MARKERS FOR ROSACEA AND USES THEREOF Galderma Research & Development (FR) 2014-09-03 EP claimed
WO-2013060865-A1 NEW LEUKOCYTE INFILTRATE MARKERS FOR ROSACEA AND USES THEREOF GALDERMA RESEARCH & DEVELOPMENT (FR) 2013-05-02 WO claimed
US-12383563-B2 Methods of reducing mammographic breast density and/or breast cancer risk Havah Therapeutics Pty Ltd. (AU) 2025-08-12 US disclosed
US-20240358715-A1 METHODS OF REDUCING MAMMOGRAPHIC BREAST DENSITY AND/OR BREAST CANCER RISK Havah Therapeutics Pty Ltd. (AU) 2024-10-31 US disclosed
US-11883414-B2 Methods of reducing mammographic breast density and/or breast cancer risk Havah Therapeutics Pty Ltd. (AU) 2024-01-30 US disclosed
EP-3209301-B1 METHODS OF REDUCING MAMMOGRAPHIC BREAST DENSITY AND/OR BREAST CANCER RISK HAVAH THERAPEUTICS PTY LTD (AU) 2023-06-07 EP disclosed
US-20220079954-A1 Methods of Reducing Mammographic Breast Density and/or Breast Cancer Risk Havah Therapeutics Pty Ltd. (AU) 2022-03-17 US disclosed
CN-113633644-A Method for reducing mammographic breast density and/or breast cancer risk 哈瓦赫治疗有限公司 2021-11-12 CN disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-7405234-B2 Bicyclic modulators of androgen receptor function BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-29 US disclosed
US-7405234-B2 Bicyclic modulators of androgen receptor function BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-29 US disclosed
US-20080108649-A1 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2008-05-08 US disclosed
US-20080108649-A1 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2008-05-08 US disclosed
US-20080108649-A1 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2008-05-08 US disclosed
US-20040181064-A1 Bicyclic modulators of androgen receptor function BRISTOL-MYERS SQUIBB COMPANY 2004-09-16 US disclosed
US-20040019063-A1 Bicyclic modulators of androgen receptor function BRISTOL-MYERS SQUIBB COMPANY 2004-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040019063-A1 Bicyclic modulators of androgen receptor function AR, NR5A1, ESRRA AR 1/4885CYP2C19 396/4885
US-20040181064-A1 Bicyclic modulators of androgen receptor function AR, NR5A1, ESRRA AR 1/4885CYP2C19 396/4885
US-20080108649-A1 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION AR, ESRRA, SHBG AR 1/4885CYP2C19 513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.