Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CD69 | Q07108 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.50 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.50 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.50 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.50 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794058 | 1.00 | BTK (0.60) | BTKJAK2JAK1TYK2STAT3 | |
| SCHEMBL16794145 | 0.88 | BTK (0.65) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL29676721 | 0.88 | BTK (0.65) | BTKJAK2CYP3A4HRH2CDK7 | |
| Hydrochloric Acid SCHEMBL29676649 | 0.88 | BTK (0.64) | BTKJAK2CYP3A4HRH2CDK7 | |
| Hydrochloric Acid SCHEMBL16794374 | 0.88 | BTK (0.64) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL16814208 | 0.88 | BTK (0.54) | BTKJAK2JAK1TYK2STAT3 | |
| SCHEMBL18179515 | 0.86 | BTK (0.55) | BTKJAK2JAK1TYK2STAT3 | |
| SCHEMBL16794433 | 0.85 | BTK (0.52) | BTKJAK2JAK1TYK2STAT3 | |
| SCHEMBL29676763 | 0.85 | BTK (0.52) | BTKJAK2JAK1TYK2STAT3 | |
| SCHEMBL23114132 | 0.83 | TBK1 (0.55) | BTKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109096274-B | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2022-07-01 | — | — | CN | disclosed |