SCHEMBL296770

SCHEMBL296770

CC1CC(C)(C)CC(c2ccc(O)c(Cl)c2)(c2ccc(O)c(Cl)c2)C1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.63
ESR2 Q92731 3/20 0.63
CCR2 P41597 7/20 0.36
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
CHRNA1 P02708 1/20 0.33
CHRNG P07510 1/20 0.33
CHRNB1 P11230 1/20 0.33
CHRNB2 P17787 1/20 0.33
SLC6A2 P23975 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
CHRND Q07001 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
EPHX2 P34913 1/20 0.32
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4425531 0.92 ESR1 (0.55) ESR1ESR2CCR2DHFR
SCHEMBL21538491 0.86 ESR1 (0.69) ESR1ESR2TSHRMEN1POLB
SCHEMBL244496 0.84 ESR1 (0.65) ESR1ESR2CCR2MEN1POLB
SCHEMBL29404012 0.84 ESR1 (0.65) ESR1ESR2CCR2MEN1POLB
SCHEMBL29459501 0.84 ESR1 (0.65) ESR1ESR2CCR2MEN1POLB
SCHEMBL298455 0.83 ESR1 (0.59) ESR1ESR2CCR2TSHRHSD17B10
SCHEMBL7909628 0.82 ESR1 (0.63) ESR1ESR2CCR2SLC6A3CHRNA1
SCHEMBL296382 0.82 ESR1 (0.63) ESR1ESR2TSHRMEN1POLB
SCHEMBL30295754 0.82 ESR1 (0.63) ESR1ESR2TSHRMEN1POLB
SCHEMBL9066016 0.81 TSHR (0.38) ESR1ESR2CCR2TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1763560-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2007-03-21 EP claimed
US-7109274-B2 Polyarylate compositions GENERAL ELECTRIC COMPANY (US) 2006-09-19 US claimed
WO-2006012161-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2006-02-02 WO claimed
US-20060004152-A1 Polyarylate compositions GENERAL ELECTRIC COMPANY 2006-01-05 US claimed
EP-1560871-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2005-08-10 EP claimed
WO-2004041907-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2004-05-21 WO claimed
US-6657038-B1 Melt condensation copolymerization of dihydroxyaromatic compounds and diphenyl carbonate derivative in presence of metal hydroxide and quaternary phosphonium salt GENERAL ELECTRIC COMPANY 2003-12-02 US claimed
US-6576739-B2 Conversion of the hindered bisphenol to the corresponding bischloroformate and subsequent treatment with an amine catalyst and an aqueous base to effect polymerization by hydrolysis and condenstation of bischloroformate groups GENERAL ELECTRIC COMPANY 2003-06-10 US claimed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US claimed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO claimed
US-11898025-B2 Polyethylene with additives for increased environmental stress crack resistance SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2024-02-13 US disclosed
US-11535732-B2 Polyethylene with polycarbonate-siloxane for increased environmental stress crack resistance SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2022-12-27 US disclosed
US-20210388189-A1 POLYETHYLENE WITH ADDITIVES FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-12-16 US disclosed
US-20210309839-A1 POLYETHYLENE WITH POLYCARBONATE-SILOXANE FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-10-07 US disclosed
EP-3877463-A1 POLYETHYLENE WITH ADDITIVES FOR INCREASED ENVIRONMENTAL STRESS CRACK RESISTANCE SABIC Global Technologies B.V. (NL) 2021-09-15 EP disclosed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US disclosed
US-6420512-B1 SCREW EXTRUSION AND ESTER INTERCHANGE GENERAL ELECTRIC COMPANY 2002-07-16 US disclosed
US-20020035234-A1 Continuous preparation of polycarbonate GENERAL ELECTRIC COMPANY 2002-03-21 US disclosed
WO-2002008311-A2 CONTINUOUS PREPARATION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2002-01-31 WO disclosed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO disclosed