Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11985300 | 0.82 | MAPT (0.38) | CNR2ALDH1A1CFTRCYP3A4MAPT | |
| SCHEMBL11985301 | 0.81 | PDGFRB (0.42) | CNR2ALDH1A1CFTRMAPTKDM4E | |
| SCHEMBL2977475 | 0.81 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TSHRRECQLGAA | |
| SCHEMBL22595337 | 0.80 | CNR2 (0.39) | CNR2ALDH1A1CFTRCYP3A4TSHR | |
| SCHEMBL2983072 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CYP3A4TSHRRECQLGAA | |
| SCHEMBL30819099 | 0.74 | MAPT (0.37) | CNR2ALDH1A1CFTRCYP3A4GAA | |
| SCHEMBL28415561 | 0.74 | ALDH1A1 (0.40) | ALDH1A1CFTRCYP3A4TSHRMAPT | |
| SCHEMBL4826271 | 0.73 | S1PR4 (0.42) | CNR2ALDH1A1CFTRMAPTLMNA | |
| SCHEMBL29532347 | 0.73 | ALDH1A1 (0.39) | ALDH1A1CFTRCYP3A4TSHRMAPT | |
| SCHEMBL22868258 | 0.73 | ALDH1A1 (0.39) | ALDH1A1CFTRCYP3A4TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781452-B2 | such as 5-(4-Fluorophenoxy)-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-3H-imidazo[4,5-b]pyridine, useful as a gastric acid secretion inhibitor, for the treatment of gastroesophageal reflux or ulcers; antisecretory agents | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-7781452-B2 | such as 5-(4-Fluorophenoxy)-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-3H-imidazo[4,5-b]pyridine, useful as a gastric acid secretion inhibitor, for the treatment of gastroesophageal reflux or ulcers; antisecretory agents | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-7781452-B2 | such as 5-(4-Fluorophenoxy)-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-3H-imidazo[4,5-b]pyridine, useful as a gastric acid secretion inhibitor, for the treatment of gastroesophageal reflux or ulcers; antisecretory agents | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| EP-1737862-A4 | IMIDAZOPYRIDINE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2007-11-28 | — | — | EP | disclosed |
| EP-1737862-A1 | IMIDAZOPYRIDINE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2007-01-03 | — | — | EP | disclosed |
| US-20060167041-A1 | such as 5-(4-Fluorophenoxy)-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-3H-imidazo[4,5-b]pyridine, useful as a gastric acid secretion inhibitor, for the treatment of gastroesophageal reflux or ulcers; antisecretory agents | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-07-27 | — | — | US | disclosed |
| US-20050272764-A1 | Imidazopyridine compound | EISAI CO., LTD. | 2005-12-08 | — | — | US | disclosed |
| WO-2005103049-A1 | IMIDAZOPYRIDINE COMPOUND | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272764-A1 | Imidazopyridine compound | H1-3, KCNH2, H1-4 | CNR2 152/4885ALDH1A1 389/4885CFTR 1934/4885 |
| US-20060167041-A1 | such as 5-(4-Fluorophenoxy)-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-3H-imidazo[4,5-b]pyridine, useful as a gastric acid secretion inhibitor, for the treatment of gastroesophageal reflux or ulcers; antisecretory agents | HRH2, HRH4, GRPR | CNR2 586/4885ALDH1A1 710/4885CFTR 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.