Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478365 | 0.83 | TSHR (0.35) | HRH2HRH1HRH3TSHR | |
| SCHEMBL24662659 | 0.83 | TSHR (0.35) | HRH2HRH1HRH3TSHR | |
| SCHEMBL23107027 | 0.83 | TSHR (0.35) | HRH2HRH1HRH3TSHR | |
| SCHEMBL14067194 | 0.80 | MEN1 (0.38) | — | |
| SCHEMBL30598302 | 0.79 | S1PR4 (0.36) | HRH2HRH1HRH3 | |
| SCHEMBL30598274 | 0.79 | S1PR4 (0.36) | HRH2HRH1HRH3 | |
| SCHEMBL29646170 | 0.79 | S1PR4 (0.36) | HRH2HRH1HRH3 | |
| SCHEMBL31733031 | 0.79 | GAA (0.33) | TSHR | |
| SCHEMBL3421093 | 0.78 | CYP3A4 (0.42) | TSHR | |
| SCHEMBL19799051 | 0.76 | KDM2B (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |