Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 5/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29080160 | 1.00 | LPL (0.35) | LPLLIPGJAK2BTK | |
| SCHEMBL183904 | 0.82 | LPL (0.42) | LPLLIPGJAK2BTK | |
| SCHEMBL29469030 | 0.82 | LPL (0.42) | LPLLIPGJAK2BTK | |
| SCHEMBL16637594 | 0.81 | LPL (0.38) | LPLLIPGJAK2BTK | |
| SCHEMBL31156286 | 0.81 | JAK2 (0.40) | LPLLIPGJAK2BTK | |
| SCHEMBL23043006 | 0.79 | JAK2 (0.41) | LPLLIPGJAK2BTK | |
| SCHEMBL29418721 | 0.79 | JAK2 (0.41) | LPLLIPGJAK2BTK | |
| SCHEMBL26197525 | 0.78 | LPL (0.33) | LPLLIPGJAK2BTK | |
| SCHEMBL23053926 | 0.78 | LPL (0.36) | LPLLIPGJAK2BTK | |
| SCHEMBL22208223 | 0.77 | LPL (0.38) | LPLLIPGJAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |