Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15367595 | 1.00 | GBA1 (0.54) | GBA1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL15817773 | 0.87 | ACHE (0.41) | GBA1SIGMAR1MAPTACHEDRD4 | |
| SCHEMBL24532601 | 0.86 | DRD4 (0.43) | GBA1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL29090896 | 0.86 | DRD4 (0.43) | GBA1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL24532342 | 0.86 | DRD4 (0.43) | GBA1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL29090894 | 0.86 | DRD4 (0.43) | GBA1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL17314312 | 0.81 | ACHE (0.45) | DRD2DRD3SIGMAR1MAPTACHE | |
| SCHEMBL15921453 | 0.81 | ACHE (0.45) | DRD2DRD3SIGMAR1MAPTACHE | |
| SCHEMBL17314984 | 0.81 | ACHE (0.45) | DRD2DRD3SIGMAR1MAPTACHE | |
| SCHEMBL15921452 | 0.81 | ACHE (0.45) | DRD2DRD3SIGMAR1MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263535-A1 | N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES | Astrazeneca AB (SE) | 2023-10-25 | — | — | EP | disclosed |
| CN-116745291-A | N- (2- (4-cyanothiazolidin-3-yl) -2-oxoethyl) -quinoline-4-carboxamide | 阿斯利康(瑞典)有限公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022130270-A1 | N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2022-06-23 | — | — | WO | disclosed |