Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613357 | 1.00 | KDM4E (0.42) | KDM4EPOLBCTDSP1HDAC1HDAC2 | |
| SCHEMBL4843924 | 0.86 | BIRC5 (0.42) | POLBHDAC1HDAC2BIRC5NOTUM | |
| SCHEMBL21984170 | 0.85 | NOTUM (0.40) | KDM4EPOLBCTDSP1BIRC5SRC | |
| SCHEMBL29516256 | 0.82 | KDM4E (0.47) | KDM4EPOLBCTDSP1CYP2D6CYP2C9 | |
| SCHEMBL16613618 | 0.82 | KDM4E (0.47) | KDM4EPOLBCTDSP1CYP2D6CYP2C9 | |
| SCHEMBL24528623 | 0.80 | ALDH1A1 (0.41) | KDM4EPOLBHDAC1HDAC2NPSR1 | |
| SCHEMBL29680986 | 0.80 | ALDH1A1 (0.41) | KDM4EPOLBHDAC1HDAC2NPSR1 | |
| SCHEMBL16613450 | 0.80 | KDM4E (0.45) | KDM4EPOLBCTDSP1CYP2D6CYP2C9 | |
| SCHEMBL16613668 | 0.76 | KDM4E (0.41) | KDM4EPOLBCTDSP1CYP2D6CYP2C9 | |
| SCHEMBL20351707 | 0.76 | SRC (0.51) | KDM4ETSHRCYP2C19SRCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263539-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022129376-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE|TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-06-23 | — | — | WO | disclosed |